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Polat
M, Lenk N,
Bingöl
S,
Oztaş
P,
Ilhan
MN,
Artüz
F,
Alli N.
Plasma homocysteine level is
elevated in patients on isotretinoin therapy for cystic acne: a prospective
controlled study.
J
Dermatolog Treat.
2008; 19 (4):229-32
The purpose
of this study was to evaluate homocysteine
(Hcy) levels, vitamin B12, and folate in patients receiving treatment with
Isotretinoin (Iso) for cystic acne. Oral isotretinoin is sold under several
trade names including Accutane and Roaccutane. Isotretinoin is commonly used
in the treatment of moderate to severe acne. It was originally developed as
a chemotherapy drug for use in cancer treatment. Iso is known to have many
adverse side effects. An elevated level of blood serum
homocysteine is a known risk factor for cardiovascular disease. Vitamin
B12 and folate have been shown to lower Hcy levels.
Study participants included
seventy-four patients with cystic acne and a control group consisting of 80
individuals. Blood levels of Hcy, vitamin B12, and folate were assessed at
baseline in all participants. Those with cystic acne were treated for forty
five days with oral isotretinoin. Those individuals were once again assessed
for serum Hcy and vitamin levels.
The study found a statistically
significant increase in blood serum
homocysteine
levels in those patients receiving isotretinoin therapy, while vitamin
levels were unaltered. That group also had statistically significant
elevated serum lipids and liver enzymes.
The study concluded that the drug may
inhibit an enzyme required in the metabolism of
homocysteine,
directly or indirectly as a result of liver dysfunction. The researchers
recommended that patients receiving isotretinoin therapy be prescribed both
vitamin B12 and folate to prevent premature coronary artery disease.
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The Risks and
Side Effects of Prescription Acne Medications